Improved structure refinement through maximum likelihood
نویسندگان
چکیده
منابع مشابه
Maximum-likelihood multi-reference refinement for electron microscopy images.
A maximum-likelihood approach to multi-reference image refinement is presented. In contrast to conventional cross-correlation refinement, the new approach includes a formal description of the noise, implying that it is especially suited to cases with low signal-to-noise ratios. Application of this approach to a cryo-electron microscopy dataset revealed two major classes for projections of simia...
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MOTIVATION Maximum-likelihood (ML) image refinement is a promising candidate to improve attainable resolution limits in 3D-EM. However, its large CPU requirements may prohibit application to 3D-structure optimization. RESULTS We speeded up ML image refinement by reducing its search space over the alignment parameters. Application of this reduced-search approach to a cryo-EM dataset yielded pr...
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The Bayesian viewpoint had long suggested that structure refinement should be performed by the MaximumLikelihood (ML) rather than the Least-Squares (LS) method.. ML refinement has been implemented by the combined use of the BUSTER and TNT programs and has been tested on a severely incomplete and imperfect model of crambin. Comparison with LS refinement in the same conditions shows that the ML r...
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Iterative localization is designed to more free nodes when the number of anchor is few. When all localizable nodes are localized in the primitive iterative localization, the reciprocal refinement localization is proposed to refine and improve the node positions. To improve the localization accuracy, the position error of pseudo anchor is transformed to the equivalent range error, the optimal we...
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An expectation-maximization algorithm for maximum-likelihood refinement of electron-microscopy images is presented that is based on fitting mixtures of multivariate t-distributions. The novel algorithm has intrinsic characteristics for providing robustness against atypical observations in the data, which is illustrated using an experimental test set with artificially generated outliers. Tests o...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 1996
ISSN: 0108-7673
DOI: 10.1107/s0108767396095700